Clinical Studies

1. Unpublished double-blind placebo controlled trial conducted in Poland on CUUR - an all-natural weight loss supplement.

2. Zheng G, Sayama K, Okubo T, Juneja LR, Oguni L, Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice.
In Vivo. 2004 Jan-Feb;18(1):55-62

3. Kao YH, Modulation of obesity by a green tea extract catechin. Am J Clin Nutr.
2000;72: 1232-41.

4. Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal caffeine consumption: Influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989 Jan:44-50.

5. Liao S. The Medicinal Action of Androgens and Green Tea Epigallocatechin Gallete. HKMJ 2001; 7(4):369-374.

6. Dulloo AG, Duret C, Rohrer D, Efficacy of a green tea extract rich in catechin
polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999, 70. 1040-5.

7. Kao, Y, Hiipakka, RA, Liao, S (2000) Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate Endocrinology 141(3):980-987.

8. Dulloo AG, Sevdoux J, Girandier L, et al. Green Tea and Thermogenesis:
Interactions Between Catechin-polyphenols, Caffeine and Sympathetic Activity. Int J Obes Relat Metab Disord. Feb2000;24(2):252-8.

9. Mukhtar et al. Tea polyphenols: prevention of cancer and optimizing health, American Journal of Clinical Nutrition, 2000; 71: 1698S-1702S.

10. Nagao et al. Tea Catechins Suppress Accumulation of Body Fat in Humans, J. Oleo Sci, 2001; 50 (9): 717-728.

11. Chow et al. Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocateckin Gallate and Polphenon E in Healthy Individuals, Clinical Cancer Research, 2003; 9: 3312-3319.

12. Westerterp-Plantenga et al. Body Weight loss and Weight Maintenance in Relation to Habitual Caffeine Intake and Green Tea Supplementation, Obesity Research, 2005; 13 (7): 1196-1204.

13. Nagao et al. Ingestion of tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men, American Journal of Clinical Nutrition, 2005;81:122-129.

14. McKenna et al. Green Tea Monograph, Alternative Therapies, 2000; 6(3): 61-84.

15. Green Tea Monograph, Alternative Medicine Review, 2000;5(4):372-375. Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807.

16. Nawrot P. Effects of caffeine on human health. Food Addit Contam. 2003
Jan;20(1):1-30.

17. Barone JJ. Caffeine consumption. Food Chem Toxicol. 1996 Jan;34(1):119-29.

18. Dorea JG. Is coffee a functional food? Br J Nutr. 2005 Jun;93(6):773-82.

19. Corti et al. Coffee Acutely Increases Sympathetic Nerve Activity and Blood Pressure Indpendently of Caffeine Content Role of Habitual Versus Nonhabitual Drinking. http://www.circulationaha.org , 2935

20. Graham et al Metabolic and exercise endurance effects of coffee and caffeine ingestion, American Physiological Society, pgs.883-889.

21. Pittler et al. Dietary supplements for body-weight reduction: a systematic review, American Journal of Clinical Nutrition, 2004; 79: 529-536.

22. Andersen et al. Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients, J Hum Nutr Dietet, 2001; 14:243-250.

23. Pittler et al. Adverse events of herbal food supplements for body weight reduction: systematic review, Obesity Reviews, 2005; 6: 93-111.

24. Kumar et al. Anti-anxiety Activity Studies on Homeopathic Formulationsof Turnera aphrodisiaca Ward, Journal and Oxford University Press, 2005: 117-119.

25. Coleus toxicology study performed at the Indian Institute of Toxicology, Pune, India.

26. Cantox Health Sciences International Safaty Report on Coleus Forskohlii

27. Godard et al. Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men, 2005; 13(8):1335-1343.

28. Bruneton, Jean. (1995) Coles forskohlii in Pharmacognosy, Phytochemistry, Medicinal Plants, Lavoisier Publishing Company, 521.

29. de Souza, N.J. (1991) Coleus forskohlii Briq.- The Indian plant source for forskolin. Recent Advances in Medicinal, Aromatic & Spice crops, (ed: S..P. Rayachaudhuri.) Today and Tomorrow and Tomorrowís printers and Publishers, New Delhi, India, Vol 1: 83-91.

30. Palou, A. , et al. (1998) The uncoupling protein, thermogenin. Int. J. Biochem. Cell Biol., 30(1):7-11.

31. Tandon, J.S et al. (1977) Ind. J. Chem., 15B : 880-883.

32. Gabetta. B., et al. (1989) Minor diterpenoids of Coleus forskohlii Phytochemistry, 28(3):859-862.

33. Ammon, H.P.T. and Muller (1989) Forskolin: from an Ayurvedic Remedy to a Modern Agent Planta Medica. Vol 51, 475-476.

34. Murray, M.T. (1995) The unique pharmacology of Coleus Forskohlii. Health Counselor 7(2): 33-35.

35. Stevens, J. et al. (1998) The body mass index-mortality relationship in white and African women. Obes. Res., 6(4):268-77.

36. Must, A. (1996) Morbidity and mortality assoiated with elevated body weight in children and adolescents. Am J. Clin Nutr. 63(3 Suppl):445S-4447S

37. Coleus Research Report, Sabinsa Corporation, 1999

38. Asano Tsuguyoshi (2001). Clinical report on root extract of perilla plant (Coleus forskohlii) ForsLean® in reducing body fat. Asano Institute. Tokyo,
Japan.

39. Kreider RB, et al. Effects of Coleus forskohlii supplementation on body composition and markers of health in sedentary overweight females. Experimental Biology 2002 Late Breaking Abstracts. LB305: 2002.

40. Study conducted at C.B. Patel Research Centre for Chemistry and Biological Sciences, Mumbai. Data on file of Sami labs Limited, Bangalore, India.

41. Allen, D.O. et al. (1986) Relationships between cuclic AMP levels and lipolysis in fat cells after isoproterenol and forskolin stimulation. The journal of Pharmacology and Experimental Therapeutics. 238(2): 659-664.

42. Haye B. et al. (1985) Chronic and acute effects of forskolin on isolated thyroid cell metabolism. Molecular and Cellular Endocrinology. 43:41-50.

43. Yajima H. et al (1999) cAMP enhances insulin secreation by an action on the
ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets. Diabetes 48(5):1006-12